Rockefeller University Seminar 2014

George A. Scheele, M.D.

Accelerated Amino Acid Delivery in the Treatment of Metabolic Disease and Aging

SUMMARY

Serious disruptions in metabolic health appear to be due to the constitutive deficiencies in essential amino acids in the food chain that lead to deficiencies in the synthesis of enzymes that drive metabolic pathways. Furthermore, the patterns of protein deficiency (loss of positive-charged proteins) observed throughout the body can be expected to result in aberrant physiological systems, including those that regulate energy balance, weight control, glucose metabolism, inflammation, blood pressure, cholesterol metabolism, cardiovascular functions and the innate immune system.

Factor4 Health represents a breakthrough in Accelerated Amino Acid Delivery Technologies (AAADT) that has profound benefits on metabolic disease and aging. This technology, which combines essential, positive-charged and satiety amino acids (Power Amino Acids®) together with backup protein, serves to increase the rate of delivery of amino acids from the digestive tract to the blood circulation more than ten to one thousand fold. The accelerated delivery of high-density nutrients, like essential amino acids, appears to have beneficial effects on the metabolic health of human subjects who suffer from the poor nutritional health associated with obesity, metabolic disease and aging.

We have developed an hypothesis that proteins enriched in Lysine [K] and Arginine [R] residues are most susceptible to amino acid deficiencies in the food chain. We have interrogated the human proteome and identified proteins with high KR values that could explain the diverse loss of metabolic functions in a number of metabolic diseases that comprise the Metabolic Syndrome. These include obesity, type-2 diabetes, lipid disorders and cardiovascular disease. Other KR-rich proteins may explain Alzheimer’s Disease and dementia.

In summary, AAADT has the potential to prevent and treat metabolic disease and aging.

GEORGE A. SCHEELE, M.D.

Dr. Scheele is a world-renowned physician, inventor, and author, who has pioneered in understanding the critical role of amino acids in regulating body weight, metabolic health and aging. He recently introduced Factor4 Weight Control® with essential ingredients to treat obesity and metabolic disease.

As a graduate of Princeton University and Johns Hopkins Medical School he served as Professors of Medicine on the faculties of The Rockefeller University, Yale University School of Medicine and Harvard Medical School. Dr. Scheele invented new concepts and techniques which “cracked the code” in understanding how Power Amino Acids® correct the deficiencies in amino acids, positive-charged proteins, and metabolic pathways that normalize body weight and restore metabolic health.

A pioneer in the development of the fields of Cell Biology and Molecular Biology and their impact on understanding chronic human diseases, he participated in work that won two Nobel Prizes in Medicine awarded in 1974 (George E. Palade) and 1999 (Gunter Blobel).

Dr. Scheele is currently the Founder, President, and CEO of NovaLife, Inc. a San-Diego based biotech company that has pioneered in the development of innovative health-care products for people who suffer from obesity and metabolic diseases, including diabetes, lipid disorders, cardiovascular disease, autoimmune disorders, and aging.