Power Amino Acids® and Factor4 Health
In Sleep Deprivation

George A. Scheele, M.D.


Between 50 and 70 million people in the United States suffer from some form of insomnia. According to the National Sleep Foundation, adults should sleep seven to nine hours. However, up to 80% of working adults suffer from some extent of sleep deprivation and on average we are getting less sleep a night than we did 50 to 100 years ago.

Sleep is especially important in myelination of nerve fibers in the brain and in removal of metabolic toxins, including beta amyloid, the offending agent in Alzheimer’s Disease, from the interstitial compartments of brain tissue.

When we are deprived of sleep we can no longer integrate or put together facts in an orderly manner. Sleep deprivation impedes our ability to concentrate, to pay attention to our environment and to analyze information creatively. Chronic wakefulness leads to degeneration of key neurons involved in alertness and proper cortical function and a buildup of proteins, including beta amyloid, that are associated with aging and neural degeneration. Even Alzheimer’s Disease and Parkinson’s disease may be accelerated by sleep deprivation.

Sleep deprivation leads to a vicious cycle: we work longer hours, become more stressed, sleep less, impair our brain’s ability to regenerate after all that hard work, and become even less able to sleep soundly.

Actigraph studies, which monitor sleep patterns, have shown that deprived sleep even leads to heart disease. When coronary artery disease was monitored by Computer Tomography (CT) scans over a 5 year follow-up period those people who averaged five or fewer hours of sleep developed coronary calcifications in 27% of their study group, whereas those that received 7 hours or more showed only 6% calcifications in their study group.

The consensus is that sleep deprivation leads to stress hormones and elevations in blood pressure, which lead to cardiovascular disease. For every additional hour that people sleep, their risk of having coronary calcifications decreased by a third, which is a huge response.

In fact, the results suggest that sleep is more important than pharmaceutical drugs, which also show multiple side effects.

Given the challenges at hand, the next miracle drug could provide improved qualities of sleep and cognitive regeneration. Factor4 Health represents the leading contender for this opportunity.


There are two types of sleep patterns, one defined by non-rapid eye movements (NREM sleep) and the other defined by rapid-eye movements (REM sleep).

NREM Sleep

Non-REM (NREM) sleep occurs early in the sleep cycle and may be divided into three stages:


  • Stage 1 – In this stage of light sleep your body functions slow down.
  • Stage 2 – This is the stage in which you spend most of your time sleeping.  During this stage your brain waves become larger with bursts of electrical activity.
  • Stages 3 and 4 both result in deep sleep patterns and provide the most restful sleep of all.  In these stages, brain waves are large and slow, and you are more difficult to awaken.


REM Sleep


REM sleep occurs later in the sleep cycle and may presage awakening.  It is characterized by the following activities:

  • During REM sleep your eyes move rapidly behind closed lids.
  • This is the period of greatest electrical activity in which your dreams occur and your body functions speed up.
  • During REM sleep your brain waves show faster electrical activity at lower amplitudes than during other sleep stages, a pattern that is more similar to the brain waves of wakefulness.
  • People awakened during REM sleep may recall vivid dreams.




Factor4 Weight Control® is the ultimate solution for sleep deprivation. In addition to promoting metabolic pathways that burn fat, Factor4 Weight Control® promotes restful sleep. This is because Factor4 appears to stimulate stage 3 and 4 of NREM sleep. Stage 3 and 4 NREM sleep is considered the most restful sleep of all. In these two stages, brain waves are large and slow, you sleep more soundly, and upon arising you feel more rested.

Some customers even take Factor4 power shakes in the middle of the night (e.g. at 4 AM) if they have difficulty in sleeping.  The following changes may be noticed as one drifts back to sleep:

  • The body becomes progressively more relaxed.  The brain is calmed.  Muscles throughout the body relax within 15 to 20 minutes, including those that control vocal cords and respiration.  Longer, deeper breathing patterns presage “falling asleep.” Sleep is normally restored within 20 to 30 minutes.
  • These feelings usually lead to 3-4 hours, or more, of deep, restful sleep, with less vivid dream patterns, suggestive of stage 3 and 4 NREM sleep, the most restful sleep of all.
  • On arising, subjects typically feel more rested and relaxed.
  • And remember, the metabolic effects of Factor4 on weight control work even as you sleep, representing an added bonus for weight loss.


Now that we have a better understanding of why sleep is so important, a new generation of drug makers can work to create the best possible environment for improved sleep…That would be Factor4 Sleep.


George A. Scheele, M.D.


Dr. Scheele is a world-renowned physician, inventor, author and two-time Nobel Associate, who has pioneered in understanding the critical role of amino acids in regulating metabolic health and body weight. He recently introduced Factor4 Weight Control® with essential ingredients to treat the four nutritional traps that lead to overweight disorders and obesity.

As a graduate of Princeton University and Johns Hopkins Medical School he served as Professors of Medicine on the faculties of The Rockefeller University, Yale University School of Medicine and Harvard Medical School. Dr. Scheele invented new concepts and techniques which “cracked the code” in understanding how Power Amino Acids® correct the deficiencies in amino acids, positive-charged proteins, and metabolic pathways that normalize body weight and restore metabolic health.

A pioneer in the development of the fields of Cell Biology and Molecular Biology and their impact on understanding chronic human diseases, he participated in work that won two Nobel Prizes in Medicine awarded in 1974 and 1999.

As a leader in nutritional science and medical research with 40 years of innovative scientific research and 10 years of breathtaking achievements in the fields of obesity and metabolic disease, Dr. Scheele’s passion has always been to “Make the World a Better Place”. After moving to La Jolla in 1998, he has utilized his vast experience to develop superior health-care products for individuals living in today’s fast-paced world.

Dr. Scheele is currently the Founder, President, and CEO of NovaLife, Inc. a San-Diego based biotech company that has pioneered in the development of innovative health-care products for people who suffer from obesity and metabolic diseases, including diabetes, lipid disorders, cardiovascular disease, autoimmune disorders, and aging.

Confidential Document: All rights reserved. No part of this document may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any other information storage and retrieval system, without the written permission of the publisher.

Disclaimer: This product is not meant to diagnose, treat, cure, or prevent any disease by the use of pharmaceutical drugs. As a dietary supplement, with all natural ingredients, considered to be “generally regarded as safe” (GRAS), Factor4 is intended only to improve health and wellness in the organs and tissues throughout the body. Comments and notations, derived from testimonials and limited human studies, have not been evaluated by the FDA. All results stated in this white paper and on our website(s) are actual results from real customers or individuals included in our clinical trials. Individual results may vary depending on personal goals and use.



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