2013: The Metabolic Mystery in Human Health

George A. Scheele, M.D.


America is suffering from poor health despite enormous strides in medical science. The statistics are clear. Since 1980 obesity in adults has doubled; obesity in children has tripled; and morbid obesity (more than 100 pounds overweight) has sextupled. To make matters worse, only one-third of Americans have been able to achieve sustained health and wellness through dietary health. The other two-thirds of Americans are suffering from an epidemic of metabolic disorders, called the Metabolic Syndrome, which is associated variously with increased levels of blood cholesterol, triglycerides, sugar and metabolic disease, including overweight disorders, hypertension, type 2 diabetes, cardiovascular disease, cancer, osteoarthritis, and gallbladder, liver & kidney disease.


The Modern American Diet (MAD) and the Standard American Diet (SAD) have now encircled the globe due to the efforts of the American food industry. Burgeoning health-care costs are challenging economies in the advanced world. What can be done for those who suffer from the epidemics of obesity and metabolic disease? More to the point, why do people not respond to simple advice on good dietary health? The current answer points to three critical factors:


  • Low quality carbohydrate and fat products, the staples of the fast food culture and affordable to the masses, provide high profit margins to the fast-food industry.


  • High quality protein products (lean meats, chicken and fish), the staples of the slow food industry, are inherently expensive.


  • Refined sugars and processed carbohydrates have now been shown to be highly addictive.


Given these overwhelming odds against dietary health, what could save the planet from the expanding epidemics of diet-related disease. Into this milieu steps Dr. George Scheele, who has conducted groundbreaking research on dietary health over the past 40 years. According to Dr. Scheele, essential amino acids are the key to a healthy planet with minimal rates of metabolic disease. However, the value of amino acids must be understood in the context of early protein deficiency that leads to an imbalance in metabolic pathways, the harbinger of poor metabolic health.




Dr. Scheele’s research showed that subjects on a high carb diet become protein deficient in the most insidious manner. While total protein levels in the blood stream remain high, a subgroup of positive-charged proteins begins to disappear from cellular tissues. According to studies conducted on laboratory subjects, the production of positive-charged proteins decreased by up to 90% within 10-12 days of being placed on protein deficient diets. During this period of time there were no changes in the production of negative-charged proteins. These studies depended on the high resolution separation of cellular proteins by 2D gel electrophoresis, a powerful technique that Dr. Scheele invented in 1975 to separate proteins in higher animals including man. Dr. Scheele now refers to this breakthrough discovery as “Selective Protein Deficiency Syndrome” or SPDS.


According to Dr. Scheele, the problem with SPDS is that it upsets the balance between metabolic pathways. Using fat metabolism as an example, what would happen if fat-storing pathways exceed fat-burning pathways…the subjects will suffer from overweight disorders and obesity.




According to Dr. Scheele, when we meet most of our caloric requirements with refined sugars and processed carbs, we are no longer motivated to eat higher quality foods enriched in protein. And here is where the concept of food costs adds insult to injury. However, a full understanding of SPDS depends upon understanding the mystery of the food chain in higher organisms. Dr. Scheele reminds us that organisms at the bottom of the food chain (plants, bacteria, yeast) produce all 20 amino acids required for protein health (amino acids are the building blocks of proteins). Organisms near the top of the food chain (fish, chicken, cows, humans) only produce 11 of these amino acids.


Based on these facts, known for more than 50 years, we call the 11 amino acids we produce non-essential amino acids (NEAA) because it is not essential that we obtain these nutrients in our diet. We call the 9 amino acids that we do not produce essential amino acids (EAAs) because it is essential that we obtain these nutrients in our diet.


According to Dr. Scheele, if we are eating a balanced diet consisting of high quality protein with modest amounts of fat and carbohydrates, we receive sufficient quantities of NEAAs and EAAs. However, if we are eating the MAD or SAD diets that are fashionable in today’s fast food culture, we quickly become deficient in dietary EAAs. The body does compensate for this deficiency by breaking down muscle tissue, but the catabolic (destructive) effects of muscle breakdown may lead to further suffering.


During his research Dr. Scheele made a number of discoveries that helped to pull the whole dietary story together in a way that can easily explain our current epidemics of obesity and metabolic disease:


  • First off, no one has really understood why higher organisms do not produce EAAs. After all, if these amino acids are essential, why do we not make them? Food scientists had believed for years that higher organisms lost the ability to produce EAAs because, well, they were so abundant in the diet. However, as Dr. Scheele has pointed out, most of the EAAs are, in fact, the least abundant amino acids in the body.


  • This led Dr. Scheele to propose a more fundamental reason for why higher organisms do not produce EAAs and one that is more consistent with evolutionary theory. Dr. Scheele points out that animals are unique in possessing muscular tissues. Since muscle tissue confers considerable advantages in searching and finding food in the environment, the evolutionary advantage may only be realized in the context of strong signals for hunger and satiety. Since evolutionary survival depends on the fundamental biological processes of nourishment and procreation, so evolutionary success is dependent on strong hunger and satiety signals.


  • Consider the appetite center (Arcuate Nucleus) in the brainstem. There are two sets of neuronal networks that regulate hunger and satiety. One network senses hunger and is therefore called “orexigenic.” The second network senses satiety, which is called “anorexigenic.”


  • So Dr. Scheele conducted research to discover which ingredients in the diet activate the hunger (orexigen) and satiety (anorexigen) networks. The results were overwhelmingly clear. High levels of EAAs signal satiety after a meal. Low levels of EAAs signal hunger before a meal. Satiety signals for EAAs trump satiety signals for sugar. Furthermore, metabolic analogs of EAAs are even more potent as satiety agents.


According to Dr. Scheele, these discoveries make enormous sense because protein deficiency maximizes hunger signals and motivates the organism to find food sources that provide nourishment and satiety. The most important food sources are protein, which is necessary for survival.




According to Dr. Scheele the best way to correct for early protein deficiencies is to take nutritional supplements containing essential and positive-charged amino acids. In addition to providing the missing dietary substrates, essential and positive-charged amino acids also provide potent signals that activate the digestive process by mobilizing the hormone cholecystokinin (CCK) to stimulate the release of pancreatic digestive enzymes and gallbladder bile into the intestinal track. This last feedback system increases the efficiency of intestinal digestion by approximately 6 times.


Dr. Scheele also points out that correction of deficiencies in positive-charged amino acids, proteins, and enzyme-driven metabolic pathways will optimize the body’s ability to burn fat stores under conditions of low insulin levels in the blood stream.




By using Eddington’s Dictum to pull all of the facts together into a cohesive theory, Dr. Scheele explains that the following simple instructions will lead to weight loss health in the great majority of people who suffer from these disorders:


  • Avoid refined sugars and processed carbs to lower blood insulin levels, in order to activate fat metabolism in the body (high blood insulin shuts off fat metabolism).


  • Correct deficiencies in the food chain, including positive-charged amino acids and proteins to rebalance metabolic pathways to optimize fat metabolism.


  • Enhance satiety to minimize hunger that leads to excessive food intake.




On this question Dr. Scheele’s comments are illuminating. Dr. Scheele believes that if the food industry returned to organic foods and beverages, America would have the chance to regain its health based on dietary intake alone. However, there are three critical factors that prevent consumers and providers from returning to normal dietary health and they are all based on what he calls the “perfect storm” of sugar addictions:


  • Consumers are addicted to sugar and high fructose corn syrup in the diet.


  • The food industry is addicted to the large profit margins associated with sugar & HFCS beverages.


  • The farmers are addicted to the $3.5 billion in government subsidies applied to the growth of corn, from which high fructose corn syrup is produced.


It is these three drivers that have led to the obsessive consumption of sugar and processed carbohydrates in the Modern American Diet (MAD) and the Standard American Diet (SAD).




The solution is a unique nutritional supplement called Factor4 Weight Control® which contains Power Amino Acids®, a combination of essential amino acids, positive-charged amino acids, and satiety amino acids. This supplement is made by NovaLife, Inc., in San Diego and may be purchased at www.factor4health.com.


Containing vitamins, minerals, micronutrients, protein and Power Amino Acids®, this nutritional supplement corrects all dietary causes of obesity as it:


  • Curbs appetite for refined sugars, processed carbohydrates and fat.


  • Satisfies hunger with minimal calories and


  • Corrects deficiencies in positive-charged amino acids, proteins and metabolic pathways to optimize fat metabolism


When Factor4 shakes and smoothies are taken according to directions, subjects become well-nourished and satiated. Factor4 provides both the amino acids and proteins that maintain anabolic (constructive) health and also reduces appetite levels to those that may be satisfied by modest but sufficient food intake. The end result is normalized weight, metabolic health and optimal longevity.



Dr. Scheele’s research has defined three important new concepts in world health by defining:


  • The molecular basis of early protein deficiency (SPDS).


  • The role of essential amino acids (EAA) and positive-charged amino acids (PAA) in maintaining body health.


  • The role of satiety amino acids (SAA) in weight control and metabolic health


According to Dr. Scheele unique nutritional supplements like Factor4 Weight Control®, containing EAAs, PAAs, and SAAs, have the potential to turn the tide in the epidemics of obesity and chronic degenerative diseases associated with the Metabolic Syndrome. With this potential in mind, Dr. Scheele has setup a nonprofit organization with the mission to Improve World Health on a grand scale, not only here in America but throughout the world. With these breakthroughs in preventive care it will also be possible to lower health-care costs to affordable levels that no longer challenge world economies.



George A. Scheele, M.D.


Dr. Scheele is a world-renowned physician, inventor, author and two-time Nobel Associate, who has pioneered in understanding the critical role of amino acids in regulating metabolic health and body weight. He recently introduced Factor4 Weight Control® with essential ingredients to treat the four nutritional traps that lead to overweight disorders and obesity.


As a graduate of Princeton University and Johns Hopkins Medical School he served as Professors of Medicine on the faculties of The Rockefeller University, Yale University School of Medicine and Harvard Medical School. Dr. Scheele invented new concepts and techniques which “cracked the code” in understanding how Power Amino Acids® correct the deficiencies in amino acids, positive-charged proteins, and metabolic pathways that normalize body weight and restore metabolic health.


A pioneer in the development of the fields of Cell Biology and Molecular Biology and their impact on understanding chronic human diseases, he participated in work that won two Nobel Prizes in Medicine awarded in 1974 and 1999.


As a leader in nutritional science and medical research with 40 years of innovative scientific research and 10 years of breathtaking achievements in the fields of obesity and metabolic disease, Dr. Scheele’s passion has always been to “Make the World a Better Place”. After moving to La Jolla in 1998, he has utilized his vast experience to develop superior health-care products for individuals living in today’s fast-paced world.


Dr. Scheele is currently the Founder, President, and CEO of NovaLife, Inc. a San-Diego based biotech company that has pioneered in the development of innovative health-care products for people who suffer from obesity and metabolic diseases, including diabetes, lipid disorders, cardiovascular disease, autoimmune disorders, and aging.



Confidential Document: All rights reserved. No part of this document may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any other information storage and retrieval system, without the written permission of the publisher.


Disclaimer: Factor4 Weight Control® is not meant to diagnose, treat, cure, or prevent any disease by the use of pharmaceutical drugs. As a dietary supplement, with all natural ingredients, considered to be “generally regarded as safe” (GRAS), Factor4 is intended only to improve health and wellness in the organs and tissues throughout the body. Comments and notations, derived from testimonials and limited human studies, have not been evaluated by the FDA. All results stated in these medical and scientific articles and on our website(s) are actual results from real customers or individuals included in our clinical trials. Individual results may vary depending on personal goals and use.




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